Alternative Versions of the Myosin Converter Vary Cross-Bridge Stiffness and Muscle Force Generation
نویسندگان
چکیده
منابع مشابه
Mutation of the myosin converter domain alters cross-bridge elasticity.
Elastic distortion of a structural element of the actomyosin complex is fundamental to the ability of myosin to generate motile forces. An elastic element allows strain to develop within the actomyosin complex (cross-bridge) before movement. Relief of this strain then drives filament sliding, or more generally, movement of a cargo. Even with the known crystal structure of the myosin head, howev...
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The recent article by Baker et al. (1999) presents a thermo-dynamic formalism that challenges the commonly held assumption that force production by muscle is localized to individual actin-bound myosin molecules. By assuming that the chemical reaction for the force-producing step is close enough to equilibrium to set ⌬G ϭ 0, the sum of the chemical and mechanical potentials of the products can b...
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Leonard TR, Herzog W. Regulation of muscle force in the absence of actin-myosin-based cross-bridge interaction. Am J Physiol Cell Physiol 299: C14–C20, 2010. First published March 31, 2010; doi:10.1152/ajpcell.00049.2010.—For the past half century, the sliding filament-based cross-bridge theory has been the cornerstone of our understanding of how muscles contract. According to this theory, acti...
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Brownian ratchet theory refers to the phenomenon that non-equilibrium fluctuations in an isothermal medium and anisotropic system can induce mechanical force and motion. This concept of noise-induced transport has motivated an abundance of theoretical and applied research. One of the exciting applications of the ratchet theory lies in the possible explanation of the operating mode of biological...
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Clear images of myosin filaments have been seen in shadowed freeze-fracture replicas of single fibers of relaxed frog semitendinosus muscles rapidly frozen using a dual propane jet freezing device. These images have been analyzed by optical diffraction and computer averaging and have been modelled to reveal details of the myosin head configuration on the right-handed, three-stranded helix of cr...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2015
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2014.11.1844